No verified data exist from the time the first church was built. All we know is that the Ottomans raised it to the ground in 1630 and its stones were later used to build a dam for the water mill by the banks of the Berettyó canal. Impoverished by tribute payments, the inhabitants could only put together a church built from reed (known as the second church).

Returning from hiding in 1700, the inhabitants of Túr (former name of Mezőtúr) began to build their third church. When the roofing was going to be installed, savage Raci launched a series of attacks on the inhabitants in 1705, spilling the blood of those who managed to find refuge in the enclosed church grounds. Those lucky few who nevertheless managed to escape the bloodshed went into hiding again. Returning only to find miserable living conditions, the inhabitants placed the construction of the remaining half of the already built church on top of their list of priorities.

The foundation of today’s Great Church was laid on 9 November 1788. This fourth church was finished in four years. Certain refurbishments were carried out in the year 1844, including replacing its hexagonal windows with rectangular ones, raising wall and tower height. The shingle roof was replaced by a tinplate roof. The church was constructed by plans made by József Hacker, a Budapest royal architect. The church itself has got a 50 metres by 25 metres surface area with a maximum height of 51 metres. When packed to capacity, it can hold up to 2,000 people sitting and 1,000 people standing inside.

The church sustained untold damage during the two world wars. During WWI in 1916, the Church sacrificed four of its bells for military purposes. The tower roof burnt down in 1944, and the newly-cast bells were irreparably damaged. The Church had its ruined bells recast. The Downtown Great Church belfry currently houses four bells weighing 1,300, 700, 400 and 300 kilograms respectively.